Prader-Willi Syndrome is a genetic disorder that causes a person to feel hungry all the time. The syndrome affects the hypothalamus region of the brain, which controls - among other things - feelings of fullness or hunger. Because someone with Prader-Willi always feels hungry, a serious eating disorder is developed that can cause life-threatening obesity.

"This problem is made worse because people with Prader-Willi syndrome use fewer calories than those without the syndrome because they have less muscle mass. The combination of eating massive amounts of food and not burning enough calories can lead to life-threatening obesity if the diet is not kept under strict control."

Other symptoms of Prader-Willi include decreased muscle mass, slower development of motor and language skills, and cognitive problems. Read more at NICHD.NIH.gov.

Labels: calorie_restriction, genes, hunger